--- This page is part of [Coy Laboratory Products](https://www.coylab.com). For a complete overview of this site's content, entity data, and subject matter expertise, see our [AI Content Index](https://www.coylab.com/llms.txt) or [Full Content Archive](https://www.coylab.com/llms-full.txt). For structured business identity data, see our [Entity Card](https://www.coylab.com/wp-json/bc-geodesic/v1/entity-card). --- # Ischemia Research > Oxygen-Glucose Deprivation (OGD) is often used by researchers to mimic the conditions of blood flow restriction caused by ischemic stroke. Coy chambers are used to create stable hypoxic or anoxic environments. **URL:** https://www.coylab.com/application/ischemia-research/ **Type:** Application **Modified:** 2025-10-13 --- ![Whitepaper news listing](https://coylab.com/wp-content/uploads/2025/07/Whitepaper-newslisting-1024x673.webp) Applications ###### Ischemia is the reduction of blood flow to tissue groups, muscles, and organs within the body, thereby limiting the supply of oxygen and other nutrients. Coy hypoxia chambers allow researchers to study the effects of reduced oxygen supply in live subjects, aiding the scientific understanding of ischemia and effective treatments to reduce ischemic damage. #### Coy hypoxia chambers have been chosen repeatedly for their reliability for *in vivo* ischemia studies, including: - **Blood-brain barrier** research demonstrating the effectiveness of preconditioning with polyinosinic polycytidylic acid to protect against [cerebral ischemic damage](https://pmc.ncbi.nlm.nih.gov/articles/PMC3481200/). - **In vitro research demonstrating autophagy** as a protective mechanism against [reperfusion injury following renal ischemia](https://ajp.amjpathol.org/article/S0002-9440(10)60432-4/pdf). - **The neuroprotectant properties** of [a certain peptide in cerebral ischemia](https://www.ahajournals.org/doi/10.1161/01.str.0000131480.03994.b1), which prevents cell death and provides an extended therapeutic window when administered after oxygen glucose deprivation. [Explore Our Chambers](/products/) ###### 168 Related Research Citations - [Enhanced Detection of Rift Valley Fever Virus using Molecular Assays on Whole Blood Samples](https://www.coylab.com/research-citation/enhanced-detection-of-rift-valley-fever-virus-using-molecular-assays-on-whole-blood-samples-2/) - [Ottawa to send second mobile laboratory](https://www.coylab.com/research-citation/ottawa-to-send-second-mobile-laboratory/) - [Another Wine Sampling Option](https://www.coylab.com/research-citation/another-wine-sampling-option/) - [Inactivation of a single gene enables microaerobic growth of the obligate anaerobe Bacteroides fragilis](https://www.coylab.com/research-citation/inactivation-of-a-single-gene-enables-microaerobic-growth-of-the-obligate-anaerobe-bacteroides-fragilis/) - [A novel human enteroid-anaerobe co-culture system to study microbial-host interaction under physiological hypoxia](https://www.coylab.com/research-citation/a-novel-human-enteroid-anaerobe-co-culture-system-to-study-microbial-host-interaction-under-physiological-hypoxia-2/) Want more? [See all Cancer Research Citations](https://coylab.com/research-citations/) COY CHAMBERS IN USE #### Explore how Coy chambers are leading the way in ischemia research. [![Ottawa to send second mobile laboratory](https://www.coylab.com/wp-content/uploads/2016/09/placeholder.avif)](https://www.coylab.com/research-citation/ottawa-to-send-second-mobile-laboratory/) ##### [Ottawa to send second mobile laboratory](https://www.coylab.com/research-citation/ottawa-to-send-second-mobile-laboratory/) [Isolation Chamber](https://www.coylab.com/citation-category/isolation-chamber/) [![Enhanced Detection of Rift Valley Fever Virus using Molecular Assays on Whole Blood Samples](https://www.coylab.com/wp-content/uploads/2016/09/placeholder.avif)](https://www.coylab.com/research-citation/enhanced-detection-of-rift-valley-fever-virus-using-molecular-assays-on-whole-blood-samples-2/) ##### [Enhanced Detection of Rift Valley Fever Virus using Molecular Assays on Whole Blood Samples](https://www.coylab.com/research-citation/enhanced-detection-of-rift-valley-fever-virus-using-molecular-assays-on-whole-blood-samples-2/) Abstract Background—Rift Valley fever (RVF) is an emerging arthropod-borne zoonoses of global… [Isolation Chamber](https://www.coylab.com/citation-category/isolation-chamber/) [![Another Wine Sampling Option](https://www.coylab.com/wp-content/uploads/2016/09/placeholder.avif)](https://www.coylab.com/research-citation/another-wine-sampling-option/) ##### [Another Wine Sampling Option](https://www.coylab.com/research-citation/another-wine-sampling-option/) Abstract Healdsburg, Calif. — Following closely on the heels of an announcement… [Anaerobic Chambers](https://www.coylab.com/citation-category/anaerobic-chambers/) [![Inactivation of a single gene enables microaerobic growth of the obligate anaerobe Bacteroides fragilis](https://www.coylab.com/wp-content/uploads/2016/09/placeholder.avif)](https://www.coylab.com/research-citation/inactivation-of-a-single-gene-enables-microaerobic-growth-of-the-obligate-anaerobe-bacteroides-fragilis/) ##### [Inactivation of a single gene enables microaerobic growth of the obligate anaerobe Bacteroides fragilis](https://www.coylab.com/research-citation/inactivation-of-a-single-gene-enables-microaerobic-growth-of-the-obligate-anaerobe-bacteroides-fragilis/) Abstract Bacteroides fragilis can replicate in atmospheres containing ≤0.05% oxygen, but higher… [Anaerobic Chambers](https://www.coylab.com/citation-category/anaerobic-chambers/) ###### Related Whitepapers See all Whitepapers [### Coy Vinyl Chambers: Key Decision Factors in Selecting the Right Chamber for Your Laboratory Coy Vinyl Anaerobic Chambers represent the industry-leading solution for anaerobic research applications, distinguished by superior citation rates in scientific literature, optimal operational economics, and stringent…](https://www.coylab.com/whitepaper/coy-vinyl-chambers-key-decision-factors-in-selecting-the-right-chamber-for-your-laboratory/) [### The Science Behind Coy Anaerobic Chambers Laboratories worldwide—whether corporate, public and private research organizations, or universities—rely upon efficient, effective, high-quality tools to conduct research in anaerobic environments. ](https://www.coylab.com/whitepaper/the-science-behind-coy-anaerobic-chambers/) ## Site Description From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs. --- **About this site:** Coy Laboratory Products — From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs.. 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