--- This page is part of [Coy Laboratory Products](https://www.coylab.com). For a complete overview of this site's content, entity data, and subject matter expertise, see our [AI Content Index](https://www.coylab.com/llms.txt) or [Full Content Archive](https://www.coylab.com/llms-full.txt). For structured business identity data, see our [Entity Card](https://www.coylab.com/wp-json/bc-geodesic/v1/entity-card). --- # Hypoxic Chambers **Archive URL:** https://www.coylab.com/citation-category/hypoxic-chambers/ **Taxonomy:** Citation Category **Post Count:** 73 --- ## Posts in Hypoxic Chambers - [A Critical Role of Interleukin-10 in Modulating Hypoxia-Induced Preeclampsia-Like Disease in Mice](https://www.coylab.com/research-citation/a-critical-role-of-interleukin-10-in-modulating-hypoxia-induced-preeclampsia-like-disease-in-mice/): Abstract Hypoxia has been implicated in the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy. However, in vivo evidence and mechanistic... - [Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development](https://www.coylab.com/research-citation/construction-of-a-zebrafish-cdna-microarray-gene-expression-profiling-of-the-zebrafish-during-development/): Abstract Vertebrate embryogenesis is a complex process controlled by a transcriptional hierarchy that coordinates the action of thousands of genes. To... - [Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival](https://www.coylab.com/research-citation/resistance-of-subventricular-neural-stem-cells-to-chronic-hypoxemia-despite-structural-disorganization-of-the-germinal-center-and-impairment-of-neuronal-and-oligodendrocyte-survival/): Abstract Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory disorders, is a... - [Reoxygenation Stress on Blood-Brain Barrier Paracellular Permeability and Edema in the Rat](https://www.coylab.com/research-citation/reoxygenation-stress-on-blood-brain-barrier-paracellular-permeability-and-edema-in-the-rat/): Abstract The blood-brain barrier (BBB) serves as a critical regulator of brain homeostasis. Following hypoxia (i.e. 6% oxygen/1hr) and reoxygenation (H/R),... - [Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury](https://www.coylab.com/research-citation/autophagy-is-a-renoprotective-mechanism-during-in-vitro-hypoxia-and-in-vivo-ischemia-reperfusion-injury/): Abstract Autophagy mediates bulk degradation and recycling of cytoplasmic constituents to maintain cellular homeostasis. In response to stress, autophagy is... - [Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans](https://www.coylab.com/research-citation/hypoxia-and-the-hif-1-transcriptional-pathway-reorganize-a-neuronal-circuit-for-oxygen-dependent-behavior-in-caenorhabditis-elegans/): Abstract Rapid behavioral responses to oxygen are generated by specialized sensory neurons that sense hypoxia and hyperoxia. On a slower time scale, many... - [Quantification of Intermediates formed during the Reduction of Nitrite by](https://www.coylab.com/research-citation/quantification-of-intermediates-formed-during-the-reduction-of-nitrite-by/): Deoxyhemoglobin Abstract Nitric oxide (NO) plays a crucial role in human physiology by regulating vascular tone and blood flow. The short life-span of NO... - [Magnetic resonance imaging of hypoxic injury to the murine placenta](https://www.coylab.com/research-citation/magnetic-resonance-imaging-of-hypoxic-injury-to-the-murine-placenta/): Deoxyhemoglobin Abstract We assessed the use of magnetic resonance imaging (MRI) to define placental hypoxic injury associated with fetal growth... - [An O2-Sensitive Glomus Cell-Stem Cell Synapse Induces Carotid Body Growth in Chronic Hypoxia](https://www.coylab.com/research-citation/an-o2-sensitive-glomus-cell-stem-cell-synapse-induces-carotid-body-growth-in-chronic-hypoxia/): Deoxyhemoglobin Abstract Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ that... - [Tobacco Smoke Chemicals Attenuate Brain-to-Blood Potassium Transport Mediated by the Na,K,2Cl-Cotransporterduring Hypoxia-Reoxygenation](https://www.coylab.com/research-citation/tobacco-smoke-chemicals-attenuate-brain-to-blood-potassium-transport-mediated-by-the-nak2cl-cotransporterduring-hypoxia-reoxygenation/): Abstract Smoking tobacco, including cigarettes, has been associated with an increased incidence and relative risk for cerebral infarction in both men and... - [Chronic Hypoxia–Induced Angiogenesis Normalizes Blood Pressure in Spontaneously Hypertensive Rats](https://www.coylab.com/research-citation/chronic-hypoxia-induced-angiogenesis-normalizes-blood-pressure-in-spontaneously-hypertensive-rats/): Abstract We hypothesized that activation of angiogenesis by chronic hypoxia may affect vascular resistance and, subsequently, blood pressure levels in... - [Flt-1 Intraceptors Inhibit Hypoxia-Induced VEGFExpression In Vitro and Corneal NeovascularizationIn Vivo](https://www.coylab.com/research-citation/flt-1-intraceptors-inhibit-hypoxia-induced-vegfexpression-in-vitro-and-corneal-neovascularizationin-vivo/): Abstract Angiogenesis, the growth of new blood vessels, is a fundamental biological process that plays a central role in the pathogenesis of cancer,... - [A reducing environment stabilizes HIF-2α in SH-SY5Y cells under hypoxic conditions](https://www.coylab.com/research-citation/a-reducing-environment-stabilizes-hif-2%ce%b1-in-sh-sy5y-cells-under-hypoxic-conditions/): Abstract Accumulating evidence suggests that hypoxia-inducible factor-2 (HIF-2) is important for the cellular response to hypoxia. However, it is not clear... - [Target gene therapy of glioma: overexpression of BAX gene under the control of both tissue-specific promoter and hypoxia-inducible element](https://www.coylab.com/research-citation/target-gene-therapy-of-glioma-overexpression-of-bax-gene-under-the-control-of-both-tissue-specific-promoter-and-hypoxia-inducible-element/): Abstract Glioma-specific transcription of tumor-killing genes has been exploited as a promising gene therapeutic modality in glioma patients. Musashi1... - [Hypoxia limits antioxidant capacity in red blood cells by altering glycolytic pathway dominance](https://www.coylab.com/research-citation/hypoxia-limits-antioxidant-capacity-in-red-blood-cells-by-altering-glycolytic-pathway-dominance/): Abstract The erythrocyte membrane is a newly appreciated platform for thiol-based circulatory signaling, and it requires robust free thiol maintenance. We... - [Hypoxia sensitization of hepatocytes to neutrophil elastase-mediated cell death depends on MAPKs and HIF-1α](https://www.coylab.com/research-citation/hypoxia-sensitization-of-hepatocytes-to-neutrophil-elastase-mediated-cell-death-depends-on-mapks-and-hif-1%ce%b1/): Abstract Sparkenbaugh EM, Ganey PE, Roth RA. Hypoxia sensitization of hepatocytes to neutrophil elastase-mediated cell death depends on MAPKs and HIF-1. Am... - [Translational repression during chronic hypoxia is dependent on glucose levels](https://www.coylab.com/research-citation/translational-repression-during-chronic-hypoxia-is-dependent-on-glucose-levels/): Abstract Translation is often repressed in cell lines that are exposed to hypoxic conditions (0.5% – 1.5% O2) but this repression requires prolonged... - [FLIP Protects against Hypoxia/Reoxygenation-Induced Endothelial Cell Apoptosis by Inhibiting Bax Activation](https://www.coylab.com/research-citation/flip-protects-against-hypoxia-reoxygenation-induced-endothelial-cell-apoptosis-by-inhibiting-bax-activation/): Abstract Hypoxia/reoxygenation causes cell death, yet the underlying regulatory mechanisms remain partially understood. Recent studies demonstrate that... - [System for exposing cultured cells to intermittent hypoxia utilizing gas permeable cultureware](https://www.coylab.com/research-citation/system-for-exposing-cultured-cells-to-intermittent-hypoxia-utilizing-gas-permeable-cultureware/): Abstract Tissue intermittent hypoxia (IH) occurs in obstructive sleep apnea, sickle cell anemia, physicalexercise and other conditions. Poor gas solubility... - [Supporting Online Material for An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis](https://www.coylab.com/research-citation/supporting-online-material-for-an-e3-ligase-possessing-an-iron-responsive-hemerythrin-domain-is-a-regulator-of-iron-homeostasis/): Abstract Non-tumorigenic immortalized human bronchial epithelial HBEC-30 cells ((S1); kindly provided by M. White), were grown in keratinocyte serum free... - [Superiority of Small Islets in Human Islet Transplantation](https://www.coylab.com/research-citation/superiority-of-small-islets-in-human-islet-transplantation/): Abstract Many factors influence the outcome of islet transplantation. As islets in the early posttransplant setting are supplied with oxygen by diffusion... - [Hypoxia-inducible Factor-1-dependent Regulation of the Multidrug Resistance ( MDR1) Gene](https://www.coylab.com/research-citation/hypoxia-inducible-factor-1-dependent-regulation-of-the-multidrug-resistance-mdr1-gene/): Abstract The microenvironment of rapidly growing tumors is associated with increased energy demand and diminished vascular supply, resulting in focal areas... - [Cytoprotective Effects of Hypoxia against Cisplatin-Induced Tubular Cell Apoptosis:](https://www.coylab.com/research-citation/cytoprotective-effects-of-hypoxia-against-cisplatin-induced-tubular-cell-apoptosis/): Involvement of Mitochondrial Inhibition and p53 Suppression Abstract Hypoxia that is caused by vascular defects or disruption is commonly associated with... - [Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels](https://www.coylab.com/research-citation/hypoxia-triggers-ampk-activation-through-reactive-oxygen-species-mediated-activation-of-calcium-release-activated-calcium-channels/): Abstract AMP-activated protein kinase (AMPK) is an energy sensor activated by increases in [AMP] or by oxidant stress (reactive oxygen species [ROS]).... - [A Phosphorescent Nanoparticle-Based Probe for Sensing and Imaging of (Intra)Cellular Oxygen in Multiple Detection Modalities](https://www.coylab.com/research-citation/a-phosphorescent-nanoparticle-based-probe-for-sensing-and-imaging-of-intracellular-oxygen-in-multiple-detection-modalities/): Abstract Monitoring cell and tissue oxygenation is important for the analysis of cell development and differentiation, mitochondrial function, and common... - [Hypoxic Induction of Interleukin-8 Gene Expression in Human Endothelial Cells](https://www.coylab.com/research-citation/hypoxic-induction-of-interleukin-8-gene-expression-in-human-endothelial-cells/): Abstract Because leukocyte-mediated tissue damage is an important component of the pathologic picture in ischemia/reperfusion, we have sought mechanisms by... - [Calcium signaling stimulates translation of F-during hypoxia](https://www.coylab.com/research-citation/calcium-signaling-stimulates-translation-of-f-during-hypoxia/): Abstract Hypoxia-inducible factors (HIFs) are ubiquitous transcription factors that mediate adaptation to hypoxia by inducing specific sets of target genes.... - [Ambient Oxygen Promotes Tumorigenesis](https://www.coylab.com/research-citation/ambient-oxygen-promotes-tumorigenesis/): Abstract Oxygen serves as an essential factor for oxidative stress, and it has been shown to be a mutagen in bacteria. While it is well established that... - [An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis](https://www.coylab.com/research-citation/an-e3-ligase-possessing-an-iron-responsive-hemerythrin-domain-is-a-regulator-of-iron-homeostasis/): Abstract Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of genes responsible for iron uptake, release, use, and... - [Nitric Oxide Synthase Inhibition Enhances the Antitumor Effect of Radiation in the Treatment of Squamous Carcinoma Xenografts](https://www.coylab.com/research-citation/nitric-oxide-synthase-inhibition-enhances-the-antitumor-effect-of-radiation-in-the-treatment-of-squamous-carcinoma-xenografts/): Abstract This study tests whether the nitric oxide synthase (NOS) inhibitor, NG-nitro-L-arginine (L-NNA), combines favorably with ionizing radiation (IR) in... - [Assessment of Cellular Oxygen Gradients with a Panel of Phosphorescent Oxygen-Sensitive Probes](https://www.coylab.com/research-citation/assessment-of-cellular-oxygen-gradients-with-a-panel-of-phosphorescent-oxygen-sensitive-probes/): Abstract The supply of oxygen (O2) to respiring tissue, cells, and mitochondria regulates metabolism, gene expression, and cell fate. Depending on the cell... - [Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells](https://www.coylab.com/research-citation/chronic-hypoxia-attenuates-vegf-signaling-and-angiogenic-responses-by-downregulation-of-kdr-in-human-endothelial-cells/): Abstract Olszewska-Pazdrak B, Hein TW, Olszewska P, Carney DH. Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR... - [Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation](https://www.coylab.com/research-citation/cerebral-microvascular-changes-in-permeability-and-tight-junctions-induced-by-hypoxia-reoxygenation/): Abstract Mark, Karen S., and Thomas P. Davis. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Am J... - [Regulation of Tumor Angiogenesis by Oxygen-regulated Protein 150, an Inducible Endoplasmic Reticulum Chaperone](https://www.coylab.com/research-citation/regulation-of-tumor-angiogenesis-by-oxygen-regulated-protein-150-an-inducible-endoplasmic-reticulum-chaperone/): Abstract Expression of angiogenic factors such as vascular endothelial growth factor (VEGF) under conditions of cell stress involves both transcriptional... - [Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing](https://www.coylab.com/research-citation/mitochondrial-complex-iii-is-required-for-hypoxia-induced-ros-production-and-cellular-oxygen-sensing/): Abstract Multicellular organisms initiate adaptive responses when oxygen (O2) availability decreases, but the underlying mechanism of O2 sensing remains... - [Hypoxia-inducible Factor-1 Mediates Neuronal Expression of the Receptor for Advanced Glycation End Products following Hypoxia/Ischemia*](https://www.coylab.com/research-citation/hypoxia-inducible-factor-1-mediates-neuronal-expression-of-the-receptor-for-advanced-glycation-end-products-following-hypoxia-ischemia/): Abstract Activation of the receptor for advanced glycation endproducts (RAGE) by its multiple ligands can trigger diverse signaling pathways with injurious... - [Nitrite Enhances RBC Hypoxic ATP Synthesis and the Release of ATP into the Vasculature: a new mechanism for nitrite induced vasodilation](https://www.coylab.com/research-citation/nitrite-enhances-rbc-hypoxic-atp-synthesis-and-the-release-of-atp-into-the-vasculature-a-new-mechanism-for-nitrite-induced-vasodilation/): Abstract A role for nitric oxide (NO) produced during the reduction of nitrite by deoxygenated RBCs in regulating vascular dilation has been proposed. It... - [Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis](https://www.coylab.com/research-citation/chordin-like-1-a-bone-morphogenetic-protein-4-antagonist-is-upregulated-by-hypoxia-in-human-retinal-pericytes-and-plays-a-role-in-regulating-angiogenesis/): Abstract Diabetic retinopathy is a microvascular complication of both Type 1 and Type 2 diabetes and is characterized by increased tissue ischemia,... - [Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose](https://www.coylab.com/research-citation/hypoxia-inducible-factor-1-confers-resistance-to-the-glycolytic-inhibitor-2-deoxy-d-glucose/): Abstract Hypoxic regions within solid tumors harbor cells that are resistant to standard chemotherapy and radiotherapy. Because oxygen is required to... - [Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of 2 integrin gene expression](https://www.coylab.com/research-citation/leukocyte-adhesion-during-hypoxia-is-mediated-by-hif-1-dependent-induction-of-2-integrin-gene-expression/): Abstract Inflammatory responses are associated with significant changes in tissue metabolism. In particular, metabolic shifts during inflammation can result... - [Differentiation of murine mast cells under physiological oxygen conditions](https://www.coylab.com/research-citation/differentiation-of-murine-mast-cells-under-physiological-oxygen-conditions/): Abstract Mast cells (MCs) are important innate immune cells mediating immune cell recruitment and antimicrobial defense. They originate from hematopoietic... - [The Transcriptional Activator Hypoxia Inducible Factor 2(HIF-2/EPAS-1) Regulates the Oxygen-Dependent Expression of Erythropoietin in Cortical Astrocytes](https://www.coylab.com/research-citation/the-transcriptional-activator-hypoxia-inducible-factor-2hif-2-epas-1-regulates-the-oxygen-dependent-expression-of-erythropoietin-in-cortical-astrocytes/): Abstract In the ischemic or hypoxic brain, astrocytes appear to be one of the main sources of erythropoietin (EPO). In this study, we investigated the... - [Mechanisms of Hypoxic Regulation of Plasminogen Activator Inhibitor-1 Gene Expression in Keloid Fibroblasts](https://www.coylab.com/research-citation/mechanisms-of-hypoxic-regulation-of-plasminogen-activator-inhibitor-1-gene-expression-in-keloid-fibroblasts/): Abstract Keloids are an excessive accumulation of extracellular matrix. Although numerous studies have shown elevated plasminogen activator inhibitor-1... - [Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1-dependent manner](https://www.coylab.com/research-citation/hypoxia-causes-an-increase-in-phagocytosis-by-macrophages-in-a-hif-1-dependent-manner/): Abstract Phagocytosis is the process by which microbial pathogens are engulfed by macrophages and neutrophils and represents the first line of defense... - [Hypoxia alters the immunomodulatory response of mast cells following Staphylococcus aureus infection](https://www.coylab.com/research-citation/hypoxia-alters-the-immunomodulatory-response-of-mast-cells-following-staphylococcus-aureus-infection/): Abstract Background: Although best known for their role in allergy and anaphylaxis, mast cells (MCs) play an important protective role against various... - [Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury](https://www.coylab.com/research-citation/chaperones-protein-aggregation-and-brain-protection-from-hypoxic-ischemic-injury/): Abstract Chaperones, especially the stress inducible Hsp70, have been studied for their potential to protect the brain from ischemic injury. While they... - [Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation](https://www.coylab.com/research-citation/antiinflammatory-adaptation-to-hypoxia-through-adenosine-mediated-cullin-1-deneddylation/): Abstract A major adaptive pathway for hypoxia is hypoxic preconditioning (HPC), a form of endogenous protection that renders cells tolerant to severe... - [Hypoxia-inducible Factor 1–dependent Induction of Intestinal Trefoil Factor Protects Barrier Function during Hypoxia](https://www.coylab.com/research-citation/hypoxia-inducible-factor-1-dependent-induction-of-intestinal-trefoil-factor-protects-barrier-function-during-hypoxia/): Abstract Mucosal organs such as the intestine are supported by a rich and complex underlying vasculature. For this reason, the intestine, and particularly... - [150-kDa Oxygen-regulated Protein (ORP150) Suppresses Hypoxia-induced Apoptotic Cell Death*](https://www.coylab.com/research-citation/150-kda-oxygen-regulated-protein-orp150-suppresses-hypoxia-induced-apoptotic-cell-death/): Abstract To determine the contribution of 150-kDa oxygen-regulated protein (ORP150) to cellular processes underlying adaptation to hypoxia, a cell line... - [Gene Expression Profiles in Livers from Diclofenac-Treated Rats Reveal Intestinal Bacteria-Dependent and -IndependentPathways Associated with Liver Injury](https://www.coylab.com/research-citation/gene-expression-profiles-in-livers-from-diclofenac-treated-rats-reveal-intestinal-bacteria-dependent-and-independentpathways-associated-with-liver-injury/): Abstract Diclofenac (DCLF) is a nonsteroidal anti-inflammatory drug that is associated with idiosyncratic adverse drug reactions in humans. Previous studies... ## Site Description From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs. --- **About this site:** Coy Laboratory Products — From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs.. [AI Content Index](https://www.coylab.com/llms.txt) | [Full Site Content](https://www.coylab.com/llms-full.txt) | [Entity Card](https://www.coylab.com/wp-json/bc-geodesic/v1/entity-card) ```json {"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://www.coylab.com/#organization","name":"Coy Laboratory Products","url":"https://www.coylab.com","description":"From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs.","disambiguatingDescription":"Laboratory equipment manufacturing company specializing in vinyl glove boxes","logo":{"@type":"ImageObject","url":"https://coylab.com/wp-content/uploads/2025/06/coylab-header_logo-svg.svg"},"address":{"@type":"PostalAddress","streetAddress":"14500 Coy Drive","addressLocality":"Grass 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