--- This page is part of [Coy Laboratory Products](https://www.coylab.com). For a complete overview of this site's content, entity data, and subject matter expertise, see our [AI Content Index](https://www.coylab.com/llms.txt) or [Full Content Archive](https://www.coylab.com/llms-full.txt). For structured business identity data, see our [Entity Card](https://www.coylab.com/wp-json/bc-geodesic/v1/entity-card). --- # A Critical Role of Interleukin-10 in Modulating Hypoxia-Induced Preeclampsia-Like Disease in Mice > Abstract Hypoxia has been implicated in the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy. However, in vivo evidence and mechanistic... **URL:** https://www.coylab.com/research-citation/a-critical-role-of-interleukin-10-in-modulating-hypoxia-induced-preeclampsia-like-disease-in-mice/ **Type:** Citation **Modified:** 2025-10-02 --- #### Abstract Hypoxia has been implicated in the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy. However, in vivo evidence and mechanistic understanding remain elusive. Preeclampsia is associated with impaired placental angiogenesis. We have recently shown that interleukin (IL)-10 can support trophoblast-driven endovascular crosstalk. Accordingly, we hypothesize that pathological levels of oxygen coupled with IL-10 deficiency induce severe preeclampsia-like features coupled with elevated production of antiangiogenic factors, apoptotic pathways, and placental injury. Exposure of pregnant wild-type and IL-10/ mice to 9.5% oxygen resulted in graded placental injury and systemic symptoms of renal pathology, proteinuria (wild-type 645.15115.73 versus 198.0993.45; IL-10/ 819.31127.85 versus 221.4582.73 g/mg/24 hours) and hypertension (wild-type 118.3714.45 versus 78.6714.07; IL-10/ 136.0322.59 versus 83.9718.25 mm Hg). Recombinant IL-10 reversed hypoxia induced features in pregnant IL-10/ mice confirming the protective role of IL-10 in preeclampsia. Hypoxic exposure caused marked elevation of soluble fms-like tyrosine kinase 1 (110.820.1 versus 44.711.9 ng/mL) in IL 10/ mice compared with their wild-type counterparts (81.613.1 versus 41.28.9 ng/mL), whereas soluble endoglin was induced to similar levels in both strains (approximately 38050 versus 18031 ng/mL). Hypoxia-induced elevation of p53 was associated with marked induction of proapoptotic protein Bax, downregulation of Bcl-2, and trophoblast-specific apoptosis in utero-placental tissue. Collectively, we conclude that severe preeclampsia pathology could be triggered under certain threshold oxygen levels coupled with intrinsic IL-10 deficiency, which lead to excessive activation of antiangiogenic and apoptotic pathways. ## Site Description From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs. --- **About this site:** Coy Laboratory Products — From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs.. [AI Content Index](https://www.coylab.com/llms.txt) | [Full Site Content](https://www.coylab.com/llms-full.txt) | [Entity Card](https://www.coylab.com/wp-json/bc-geodesic/v1/entity-card) ```json {"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://www.coylab.com/#organization","name":"Coy Laboratory Products","url":"https://www.coylab.com","description":"From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs.","disambiguatingDescription":"Laboratory equipment manufacturing company specializing in vinyl glove boxes","logo":{"@type":"ImageObject","url":"https://coylab.com/wp-content/uploads/2025/06/coylab-header_logo-svg.svg"},"address":{"@type":"PostalAddress","streetAddress":"14500 Coy Drive","addressLocality":"Grass Lake","addressRegion":"MI","postalCode":"49240"},"telephone":"734.475.2200","email":"sales@coylab.com","foundingDate":"1969","areaServed":"Global","sameAs":["https://www.linkedin.com/company/107172311","https://maps.app.goo.gl/o2txKDMScV1pV7w59","https://www.pharmaceutical-tech.com/suppliers/coy-laboratory","https://craft.co/coy-laboratory-products-inc"],"founder":[{"@type":"Person","name":"Richard Coy"},{"@type":"Person","name":"Brian Coy","sameAs":"https://www.linkedin.com/in/brian-coy-5722515/"},{"@type":"Person","name":"Ashley Coy","sameAs":"https://www.linkedin.com/in/ashley-coy-6b22705/"}],"knowsAbout":[{"@type":"Thing","name":"laboratory equipment","sameAs":"https://www.wikidata.org/wiki/Q834028"},"vinyl anaerobic chambers","vinyl hypoxic chambers","laboratory glove boxes","laboratory chamber sensors",{"@type":"Thing","name":"life sciences","sameAs":"https://www.wikidata.org/wiki/Q864928"},{"@type":"Thing","name":"microbiology","sameAs":"https://www.wikidata.org/wiki/Q7193"},{"@type":"Thing","name":"medical research","sameAs":"https://www.wikidata.org/wiki/Q2752427"}]},{"@type":"WebSite","@id":"https://www.coylab.com/#website","name":"Coy Laboratory Products","url":"https://www.coylab.com","publisher":{"@id":"https://www.coylab.com/#organization"},"potentialAction":{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://www.coylab.com/?s={search_term_string}"},"query-input":"required name=search_term_string"},"hasPart":[{"@type":"DigitalDocument","name":"LLM Content Index","url":"https://www.coylab.com/llms.txt","encodingFormat":"text/markdown","description":"AI-readable index of site content, entity data, and subject matter expertise"},{"@type":"DigitalDocument","name":"LLM Full Content","url":"https://www.coylab.com/llms-full.txt","encodingFormat":"text/markdown","description":"Complete AI-readable site content"}]},{"@type":"ItemList","@id":"https://www.coylab.com/#site-navigation","name":"Site Navigation","itemListElement":[{"@type":"SiteNavigationElement","position":1,"name":"Products","url":"#"},{"@type":"SiteNavigationElement","position":2,"name":"Applications","url":"#"},{"@type":"SiteNavigationElement","position":3,"name":"Custom","url":"#"},{"@type":"SiteNavigationElement","position":4,"name":"Sales","url":"#"},{"@type":"SiteNavigationElement","position":5,"name":"Resources","url":"#"},{"@type":"SiteNavigationElement","position":6,"name":"Contact Us","url":"#"}]},{"@type":"BreadcrumbList","@id":"https://www.coylab.com/research-citation/a-critical-role-of-interleukin-10-in-modulating-hypoxia-induced-preeclampsia-like-disease-in-mice/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.coylab.com"},{"@type":"ListItem","position":2,"name":"Citations","item":"https://www.coylab.com/research-citations/"},{"@type":"ListItem","position":3,"name":"Hypoxic Chambers","item":"https://www.coylab.com/citation-category/hypoxic-chambers/"},{"@type":"ListItem","position":4,"name":"A Critical Role of Interleukin-10 in Modulating Hypoxia-Induced Preeclampsia-Like Disease in Mice"}]},{"@type":"WebPage","@id":"https://www.coylab.com/research-citation/a-critical-role-of-interleukin-10-in-modulating-hypoxia-induced-preeclampsia-like-disease-in-mice/#webpage","url":"https://www.coylab.com/research-citation/a-critical-role-of-interleukin-10-in-modulating-hypoxia-induced-preeclampsia-like-disease-in-mice/","name":"A Critical Role of Interleukin-10 in Modulating Hypoxia-Induced Preeclampsia-Like Disease in Mice | Coy Laboratory Products","isPartOf":{"@id":"https://www.coylab.com/#website"},"breadcrumb":{"@id":"https://www.coylab.com/research-citation/a-critical-role-of-interleukin-10-in-modulating-hypoxia-induced-preeclampsia-like-disease-in-mice/#breadcrumb"},"description":"Scientists around the world have relied on Coy chambers to conduct groundbreaking research into cancer growth, the human microbiome, c-diff., and more.","about":[{"@type":"Thing","name":"Hypoxic Chambers"}]},{"@type":"ScholarlyArticle","@id":"https://www.coylab.com/research-citation/a-critical-role-of-interleukin-10-in-modulating-hypoxia-induced-preeclampsia-like-disease-in-mice/#scholarlyarticle","headline":"A Critical Role of Interleukin-10 in Modulating Hypoxia-Induced Preeclampsia-Like Disease in Mice","url":"https://www.coylab.com/research-citation/a-critical-role-of-interleukin-10-in-modulating-hypoxia-induced-preeclampsia-like-disease-in-mice/","datePublished":"2025-09-18T00:13:50+00:00","dateModified":"2025-10-02T20:22:09+00:00","isPartOf":{"@id":"https://www.coylab.com/#website"},"description":"Scientists around the world have relied on Coy chambers to conduct groundbreaking research into cancer growth, the human microbiome, c-diff., and more.","author":{"@id":"https://www.coylab.com/author/buildcreate/#person"},"publisher":{"@id":"https://www.coylab.com/#organization"}},{"@type":"Person","@id":"https://www.coylab.com/author/buildcreate/#person","name":"buildcreate","url":"https://www.coylab.com/author/buildcreate/"}]} ```