--- This page is part of [Coy Laboratory Products](https://www.coylab.com). For a complete overview of this site's content, entity data, and subject matter expertise, see our [AI Content Index](https://www.coylab.com/llms.txt) or [Full Content Archive](https://www.coylab.com/llms-full.txt). For structured business identity data, see our [Entity Card](https://www.coylab.com/wp-json/bc-geodesic/v1/entity-card). --- # Calcium signaling stimulates translation of F-during hypoxia > Abstract Hypoxia-inducible factors (HIFs) are ubiquitous transcription factors that mediate adaptation to hypoxia by inducing specific sets of target genes.... **URL:** https://www.coylab.com/research-citation/calcium-signaling-stimulates-translation-of-f-during-hypoxia/ **Type:** Citation **Modified:** 2025-10-02 --- #### Abstract Hypoxia-inducible factors (HIFs) are ubiquitous transcription factors that mediate adaptation to hypoxia by inducing specific sets of target genes. It is well accepted that hypoxia induces accumulation and activity of HIFs by causing stabilization of their subunits. We have demonstrated that hypoxia stimulates translation of HIF-1 and -2 proteins by distributing HIF- mRNAs to larger polysome fractions. This requires influx of extracellular calcium, stimulation of classical protein kinase C- (cPKC-), and the activity of mammalian target of rapamycin, mTOR. The translational component contributes to 40 –50% of HIF-proteins accumulation after 3 h of 1% O2. Hypoxia also inhibits general protein synthesis and mTOR activity; however, cPKC- inhibitors or rapamycin reduce mTOR activity and total protein synthesis beyond the effects of hypoxia alone. These data show that during general inhibition of protein synthesis by hypoxia, cap-mediated translation of selected mRNAs is induced through the mTOR pathway. We propose that calcium-induced activation of cPKC- hypoxia partially protects an activity of mTOR from hypoxic inhibition. These results provide an important physiologic insight into the mechanism by which hypoxia-stimulated influx of calcium selectively induces the translation of mRNAs necessary for adaptation to hypoxia under conditions repressing general protein synthesis.—Hui, A. S., Bauer, A. L., Striet, J. B., Schnell, P. O., Czyzyk-Krzeska, M. F. Calcium signaling stimulates translation of F- during hypoxia. FASEB J. 20, 466 – 475 (2006) ## Site Description From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs. --- **About this site:** Coy Laboratory Products — From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs.. 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