--- This page is part of [Coy Laboratory Products](https://www.coylab.com). For a complete overview of this site's content, entity data, and subject matter expertise, see our [AI Content Index](https://www.coylab.com/llms.txt) or [Full Content Archive](https://www.coylab.com/llms-full.txt). For structured business identity data, see our [Entity Card](https://www.coylab.com/wp-json/bc-geodesic/v1/entity-card). --- # Magnetic resonance imaging of hypoxic injury to the murine placenta > Deoxyhemoglobin Abstract We assessed the use of magnetic resonance imaging (MRI) to define placental hypoxic injury associated with fetal growth... **URL:** https://www.coylab.com/research-citation/magnetic-resonance-imaging-of-hypoxic-injury-to-the-murine-placenta/ **Type:** Citation **Modified:** 2025-10-02 --- Deoxyhemoglobin #### Abstract We assessed the use of magnetic resonance imaging (MRI) to define placental hypoxic injury associated with fetal growth restriction (FGR). On embryonic day 18.5 (E18.5) we utilized dynamic contrast-enhanced (DCE) MRI on a 4.7 tesla small-animal scanner to examine the uptake and distribution of gadolinium-based contrast agent. Quantitative DCE parameter analysis was performed for the placenta and fetal kidneys of three groups of pregnant C57BL/6 mice: (a) mice that were exposed to FiO2=12% between E15.5 and E18.5, (b) mice in normoxia with food restriction similar to the intake of hypoxic mice between E15.5-E18.5, and (c) mice in normoxia that were fed ad libitum. After imaging we assessed feto-placental weight, placental histology and gene expression. We found that dams exposed to hypoxia exhibited FGR (weight reduction by 28% and 14% respectively, p<0.05) with increased placental-fetal ratio. Using MRI-based assessment of placental contrast-agent kinetics, referenced to maternal paraspinous muscle, we found decreased placental clearance of contrast media in hypoxic mice, compared to either control group (61%, p<0.05). This was accompanied by diminished contrast accumulation in the hypoxic fetal kidneys (23%, p<0.05), reflecting reduced trans-placental gadolinium transport. These changes were associated with increased expression of placental Phlda2 and Gcm1 transcripts. Exposure to hypoxia near the end of mouse pregnancy reduces placental perfusion and clearance of contrast. MRI-based DCE imaging provides a novel tool for dynamic, in vivo assessment of placental function. ## Site Description From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs. --- **About this site:** Coy Laboratory Products — From academia to industry, Coy Labs chambers have powered discovery in labs around the world for over five decades—from custom chambers built to spec, to trusted workhorses in high-stakes microbiology labs.. 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